<SEC-DOCUMENT>0001388171-12-000002.txt : 20120727
<SEC-HEADER>0001388171-12-000002.hdr.sgml : 20120727
<ACCEPTANCE-DATETIME>20120727161727
ACCESSION NUMBER:		0001388171-12-000002
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20120727
DATE AS OF CHANGE:		20120727
GROUP MEMBERS:		CAXTON CORP
GROUP MEMBERS:		CXSYNTA LLC
GROUP MEMBERS:		KOVNER 2011-A INVESTMENT TRUST
GROUP MEMBERS:		KOVNER 2011-B INVESTMENT TRUST
GROUP MEMBERS:		KOVNER 2011-C INVESTMENT TRUST
GROUP MEMBERS:		KOVNER 2011-D INVESTMENT TRUST
GROUP MEMBERS:		KOVNER 2012-A SYNTA INVESTMENT TRUST
GROUP MEMBERS:		KOVNER 2012-B SYNTA INVESTMENT TRUST
GROUP MEMBERS:		KOVNER 2012-C SYNTA INVESTMENT TRUST
GROUP MEMBERS:		KOVNER 2012-D SYNTA INVESTMENT TRUST
GROUP MEMBERS:		MR. BRUCE S. KOVNER
GROUP MEMBERS:		MR. DAVID BEN-UR

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SYNTA PHARMACEUTICALS CORP
		CENTRAL INDEX KEY:			0001157601
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-82674
		FILM NUMBER:		12990853

	BUSINESS ADDRESS:	
		STREET 1:		45 HARTWELL AVE
		CITY:			LEXINGTON
		STATE:			MA
		ZIP:			02421
		BUSINESS PHONE:		781-274-8200

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CxSynta LLC
		CENTRAL INDEX KEY:			0001388171
		IRS NUMBER:				020604347
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		731 ALEXANDER ROAD
		STREET 2:		BUILDING 2
		CITY:			PRINCETON
		STATE:			NJ
		ZIP:			08540
		BUSINESS PHONE:		609-419-1800

	MAIL ADDRESS:	
		STREET 1:		731 ALEXANDER ROAD
		STREET 2:		BUILDING 2
		CITY:			PRINCETON
		STATE:			NJ
		ZIP:			08540
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>synta13damd5.txt
<DESCRIPTION>SC 13D - - SYNTA PHARMACEUTICALS AMEND 5
<TEXT>


			SECURITIES AND EXCHANGE COMMISSION
		     	     Washington, D.C. 20549

			          SCHEDULE 13D
		      Under the Securities Exchange Act of 1934

				(Amendment No. 5)

		     	    Synta Pharmaceuticals Corp.
		       		 (Name of Issuer)

			  	   Common Stock
		 	  (Title of Class of Securities)

				    87162T206
			          (CUSIP Number)

			     Mr. Scott B. Bernstein
			       Caxton Corporation
			   731 Alexander Road, Bldg. 2
			   Princeton, New Jersey 08540
			         (609) 419-1800
          (Name, Address and Telephone Number of Person Authorized to
                       Receive Notices and Communications)

			  	    7/25/2012
             (Date of Event which Requires Filing of this Statement)


If the filing person has previously filed a statement on Schedule 13G to
report the acquisition that is the subject of this Schedule 13D, and is
filing this schedule because of Section 240.13d-1(e), 240.13d-1(f) or
240.13d-1(g), check the following box. | |

Note:  Schedules filed in paper format shall include a signed original and
five copies of the schedule, including all exhibits.  See Section
240.13d-7 for other parties to whom copies are to be sent.

*The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class
of securities, and for any subsequent amendment containing information
which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).


 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    CxSynta LLC
    02-0604347

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    WC

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    Delaware

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    7,761,716

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    7,761,716

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    7,761,716

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     12.6%

 (14) Type of Reporting Person (See Instructions).
     OO

(1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Caxton Corporation
    22-2437619

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    AF

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    Delaware

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    7,761,716

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    7,761,716

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    7,761,716

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     12.6%

 (14) Type of Reporting Person (See Instructions).
    CO

(1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2011-A Investment Trust

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    125,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    125,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    125,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.2%

 (14) Type of Reporting Person (See Instructions).
    OO


(1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2011-B Investment Trust

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    125,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    125,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    125,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.2%

 (14) Type of Reporting Person (See Instructions).
    OO

(1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2011-C Investment Trust

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    125,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    125,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    125,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.2%

 (14) Type of Reporting Person (See Instructions).
    OO

(1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2011-D Investment Trust

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    125,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    125,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    125,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.2%

 (14) Type of Reporting Person (See Instructions).
    OO

(1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2012-A Synta Investment Trust

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    475,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
   475,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    475,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.8%

 (14) Type of Reporting Person (See Instructions).
    OO

(1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2012-B Synta Investment Trust

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    475,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    475,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    475,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.8%

 (14) Type of Reporting Person (See Instructions).
    OO

(1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2012-C Synta Investment Trust

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    475,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    475,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    475,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.8%

 (14) Type of Reporting Person (See Instructions).
    OO

(1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2012-D Synta Investment Trust

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    475,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    475,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    475,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.8%

 (14) Type of Reporting Person (See Instructions).
    OO

(1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Ben-Ur, David

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    PF

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    United States

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    2,700

 (8) Shared Voting Power:
    0

 (9) Sole Dispositive Power:
    2,700

 (10) Shared Dispositive Power:
    0

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    2,700

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.0%

 (14) Type of Reporting Person (See Instructions).
     IN

(1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner, Bruce

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    AF,PF

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    United States

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    8,083,539

 (8) Shared Voting Power:
    10,161,716

 (9) Sole Dispositive Power:
    8,083,539

 (10) Shared Dispositive Power:
    10,161,716

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    18,245,255

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     29.5%

 (14) Type of Reporting Person (See Instructions).
     IN


Item 3.  Source and Amount of Funds or Other Consideration

     Item 3 is hereby amended by adding the following thereto:

      Mr. Kovner has expended, in aggregate, approximately $56,763,958
      (excluding commissions, if any) to acquire 10,354,480 shares of
      Synta Pharmaceuticals Corp.  The purchase price for the shares of
      Common Stock acquired by Mr. Kovner was paid out of Mr. Kovner's
      personal funds.  52,372 of the outstanding shares of Common Stock
      directly owned by Mr. Kovner were issued to Mr. Kovner as
      compensation for his service on the Company's Board of Directors
      or certain of its committees.  Mr. Kovner also was granted
      76,687 options on the Common Stock of the Company as compensation in
      connection with his service on the Company's Board of Directors.

      CxSynta has expended an aggregate of approximately $92,662,085
      (excluding commissions, if any) to purchase the 7,761,716 shares
      of Common Stock directly owned by it.  The purchase price for such
      acquired shares was paid out of CxSynta working capital.

      Mr. David Ben-Ur has expended, in aggregate, approximately
      $14,678 (excluding commissions) to acquire 2,700 shares of the
      Company.

      Each of the trusts listed herein have received their respective
      shares of Common Stock of the Company as gifts from Mr. Kovner.


Item 4.  Purpose of Transaction.

      Each of the shares of Common Stock of the Company that are
      indicated herein were acquired for investment purposes.  Based on
      a review of the investment, each of the Reporting Persons may, in
      the open market or otherwise, acquire, cause to be acquired,
      dispose of, or cause to be disposed of, Common Stock or other
      securities of the Company, or derivatives or other instruments
      related to the securities of the Company.

      Mr. Kovner currently serves as a Director of the Company.  In that
      capacity, he participates in the ordinary course in Board of
      Directors' related activities and may participate in the management
      of the Company.

      Except as set forth in this Schedule 13D, none of the reporting
      persons has any plans or proposals that relate to any of the matters
      referred to in paragraphs (a) through (j) of the instructions to Item 4
      of Schedule 13D.

Item 5.  Interest in Securities of the Issuer

     Subparagraph (a), (b) and (c) of Item 5 of the Schedule 13D is
     hereby amended and replaced by the following:

(a)  (i) CxSynta LLC beneficially owns 7,761,716 shares of Common Stock,
      representing approximately 12.6% of the 61,789,657 shares of Common
      Stock reported to be outstanding in the Company's Prospectus
      Supplement filed with the Securities and Exchange Commission on July
      26, 2012. The percentages used herein and in the rest of this Amendment
      No. 5 are calculated based upon such number of outstanding shares.

     (ii) Caxton Corporation is the managing member of CxSynta LLC and as
      such, has voting and dispositive power with respect to the 7,761,716
      shares beneficially owned by CxSynta LLC.  As a result, Caxton
      Corporation may be deemed to beneficially own 7,761,716 shares of
      Common Stock, representing approximately 12.6% of the total shares
      of Common Stock issued and outstanding.

     (iii) Kovner 2011-A Investment Trust beneficially owns 125,000 shares
     of Common Stock, representing approximately 0.2% of the total shares of
     Common Stock issued and outstanding.  Mr. Kovner may be deemed to
     indirectly have voting and dispositive power with respect to such
     125,000 shares.  As a result, Mr. Kovner may be deemed to beneficially
     own 125,000 shares of Common Stock, representing approximately 0.2%
     of the total shares of Common Stock issued and outstanding.

     (iv)  Kovner 2011-B Investment Trust beneficially owns 125,000 shares
     of Common Stock, representing approximately 0.2% of the total shares of
     Common Stock issued and outstanding.  Mr. Kovner may be deemed to
     indirectly have voting and dispositive power with respect to such
     125,000 shares.  As a result, Mr. Kovner may be deemed to beneficially
     own 125,000 shares of Common Stock, representing approximately 0.2%
     of the total shares of Common Stock issued and outstanding.

     (v)   Kovner 2011-C Investment Trust beneficially owns 125,000 shares
     of Common Stock, representing approximately 0.2% of the total shares of
     Common Stock issued and outstanding.  Mr. Kovner may be deemed to
     indirectly have voting and dispositive power with respect to such
     125,000 shares.  As a result, Mr. Kovner may be deemed to beneficially
     own 125,000 shares of Common Stock, representing approximately 0.2%
     of the total shares of Common Stock issued and outstanding.

     (vi)  Kovner 2011-D Investment Trust beneficially owns 125,000 shares
     of Common Stock, representing approximately 0.2% of the total shares of
     Common Stock issued and outstanding.  Mr. Kovner may be deemed to
     indirectly have voting and dispositive power with respect to such
     125,000 shares.  As a result, Mr. Kovner may be deemed to beneficially
     own 125,000 shares of Common Stock, representing approximately 0.2%
     of the total shares of Common Stock issued and outstanding.

     (vii) Kovner 2012-A Synta Investment Trust beneficially owns 475,000
     shares of Common Stock, representing approximately 0.8% of the total
     shares of Common Stock issued and outstanding.  Mr. Kovner may be
     deemed to indirectly have voting and dispositive power with respect to
     such 475,000 shares.  As a result, Mr. Kovner may be deemed to
     beneficially own 475,000 shares of Common Stock, representing
     approximately 0.8% of the total shares of Common Stock issued and
     outstanding.

     (viii)Kovner 2012-B Synta Investment Trust beneficially owns 475,000
     shares of Common Stock, representing approximately 0.8% of the total
     shares of Common Stock issued and outstanding.  Mr. Kovner may be
     deemed to indirectly have voting and dispositive power with respect to
     such 475,000 shares.  As a result, Mr. Kovner may be deemed to
     beneficially own 475,000 shares of Common Stock, representing
     approximately 0.8% of the total shares of Common Stock issued and
     outstanding.

     (ix)  Kovner 2012-C Synta Investment Trust beneficially owns 475,000
     shares of Common Stock, representing approximately 0.8% of the total
     shares of Common Stock issued and outstanding.  Mr. Kovner may be
     deemed to indirectly have voting and dispositive power with respect to
     such 475,000 shares.  As a result, Mr. Kovner may be deemed to
     beneficially own 475,000 shares of Common Stock, representing
     approximately 0.8% of the total shares of Common Stock issued and
     outstanding.

     (x)   Kovner 2012-D Synta Investment Trust beneficially owns 475,000
     shares of Common Stock, representing approximately 0.8% of the total
     shares of Common Stock issued and outstanding.  Mr. Kovner may be
     deemed to indirectly have voting and dispositive power with respect to
     such 475,000 shares.  As a result, Mr. Kovner may be deemed to
     beneficially own 475,000 shares of Common Stock, representing
     approximately 0.8% of the total shares of Common Stock issued and
     outstanding.

     (xi) Mr. Ben-Ur is the Chief Investment Officer of Caxton Alternative
      Management LP and has sole beneficial ownership of 2,700 shares of
      Common Stock, representing approximately 0.0% of the total shares of
      Common Stock issued and outstanding.

     (xii) Mr. Kovner has sole beneficial ownership of 8,083,539 shares of
      Common Stock, which includes options to purchase 76,687 shares of
      Common Stock upon the exercise of such options.  In addition, Mr. Kovner
      is the Chairman and sole shareholder of Caxton Corporation, the managing
      member of CxSynta LLC, and as a result may be deemed to beneficially
      own the securities of the Company owned by CxSynta LLC.  Mr. Kovner may
      be deemed to indirectly have voting and dispositive power with respect
      to each of the following trusts and, as a result, may be deemed to
      beneficially own the 2,400,000 securities of the Company owned by such
      trusts, in aggregate: Kovner 2012-A Synta Investment Trust; Kovner
      2012-B Synta Investment Trust; Kovner 2012-C Synta Investment Trust;
      Kovner 2012-D Synta Investment Trust; Kovner 2011-A Investment Trust;
      2011-B Investment Trust; 2011-C Investment Trust; and 2011-D
      Investment Trust.  As a result of the foregoing, Mr. Kovner may be
      deemed to beneficially own an aggregate of 18,245,255 shares of Common
      Stock, representing approximately 29.5% of the total shares of Common
      Stock issued and outstanding.

      Mr. Kovner disclaims beneficial ownership of the shares of Common Stock
      owned directly by CxSynta LLC, except to the extent of his pecuniary
      interest therein.  Mr. Kovner also disclaims beneficial ownership of the
      shares of Common Stock directly owned by each of the aforementioned
      trusts.


(b)   Caxton Corporation and Mr. Kovner, as Chairman and sole shareholder of
      Caxton Corporation, the managing member of CxSynta LLC, may be deemed to
      share voting and dispositive power over 7,761,716 shares of Common Stock
      owned directly by CxSynta LLC.  Mr. Kovner may be deemed to share voting
      and dispositive power with respect to the aggregate 2,400,000 shares of
      Common Stock held by the following trusts: Kovner 2011-A Investment
      Trust, Kovner 2011-B Investment Trust, Kovner 2011-C Investment Trust,
      Kovner 2011-D Investment Trust, Kovner 2012-A Synta Investment Trust,
      Kovner 2012-B Synta Investment Trust, Kovner 2012-C Synta Investment
      Trust, and Kovner 2012-D Synta Investment Trust.  Mr. Ben-Ur has sole
      voting and dispositive power over the 2,700 shares of Common Stock
      owned directly by him.  In addition, Mr. Kovner has sole voting and
      dispositive power with respect to the 8,083,539 shares of Common Stock
      (which includes the options thereon) that he directly beneficially owns.


(c)   On July 25, 2012, Mr. Kovner acquired 3,081,664 shares of Common Stock
      at a price of $6.49 per share from the Company.  Such shares were
      purchased pursuant to the terms of the Company's Prospectus Supplement
      and the Subscription Agreement contained as an Exhibit to the Company's
      8-K filed with the Securities and Exchange Commission on July 26, 2012.
      On June 29, 2012, Mr. Ben-Ur purchased 2,700 shares of Common Stock of
      the Company at an average cost of $5.45.  On June 29, 2012, Mr. Kovner
      transferred, as gifts, 475,000 shares of Common Stock of the Company to
      each of the following trusts (for an aggregate 1,900,000 shares of
      Common Stock of the Company): Kovner 2012-A Synta Investment Trust,
      Kovner 2012-B Synta Investment Trust, Kovner 2012-C Synta Investment
      Trust, and Kovner 2012-D Synta Investment Trust.  On July 1, 2012 Mr.
      Kovner received shares of Common Stock of the Company in the amounts of
      (a) 7,312, (b) 914, and (c) 914, and 10,000 options on Common Stock of
      the Company, as compensation for his service on the Company's Board of
      Directors or on certain of its committees.

      Except as reported in this statement on Schedule 13D, the Reporting
      Persons are not believed to have engaged in any other transactions in
      the Company's securities in the past sixty (60) days.


Item 6.  Contracts, Arrangements, Understandings or Relationships
         with Respect to Securities of the Issuer.

      Item 6 is hereby amended by adding the following thereto:

      The information contained in Item 5 of this Amendment No.5 is
      incorporated by reference.

      Mr. Ben-Ur serves as Chief Investment Officer of Caxton Alternative
      Management LP, an entity indirectly controlled by Mr. Kovner and as
      such has agreed, during the course of his employment with Caxton
      Alternative Management LP, to abide by certain policies and
      procedures applicable to Mr. Kovner as a Director of the Company.
      By reason of this agreement, Mr. Kovner and Mr. Ben-Ur may be deemed
      to be members of a group.  Mr. Kovner, Mr. Ben-Ur and all other
      Reporting Persons named herein, expressly disclaim beneficial
      ownership of the Common Stock of the other Reporting Persons, except
      to the extent they may have an interest in such other Reporting
      Person.

      Except as set forth herein, there are no contracts, arrangements,
      understandings or relationships (legal or otherwise) among the persons
      filing this Report or the Reporting Persons or between such persons and
      any other person with respect to any securities of the Company,
      including, but not limited to transfer or voting of any of the
      securities, finder's fees, joint ventures, loan or option
      arrangements, puts or calls, guarantees of profits, division of profits
      or losses, or the giving or withholding of proxies.

Item 7.  Material to Be Filed as Exhibits


Signature


After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

					CxSynta LLC

Date: 07/27/2012			By Caxton Corporation, Managing Member
	                                of CxSynta LLC,
                                        by /s/ Scott B. Bernstein,
					Secretary of Caxton Corporation

					Caxton Corporation

Date: 07/27/2012			/s/ Scott B. Bernstein, Secretary of
					Caxton Corporation


Date: 07/27/2012			Kovner 2011-A Investment Trust

					/s/ Peter P. D'Angelo, President of
					Cadence Trust Company, Trustee

Date: 07/27/2012			Kovner 2011-B Investment Trust

					/s/ Peter P. D'Angelo, President of
					Cadence Trust Company, Trustee

Date: 07/27/2012			Kovner 2011-C Investment Trust

					/s/ Peter P. D'Angelo, President of
					Cadence Trust Company, Trustee

Date: 07/27/2012			Kovner 2011-D Investment Trust

					/s/ Peter P. D'Angelo, President of
					Cadence Trust Company, Trustee

Date: 07/27/2012			Kovner 2012-A Synta Investment Trust

					/s/ Peter P. D'Angelo, President of
					Cadence Trust Company, Trustee

Date: 07/27/2012			Kovner 2012-B Synta Investment Trust

					/s/ Peter P. D'Angelo, President of
					Cadence Trust Company, Trustee

Date: 07/27/2012			Kovner 2012-C Synta Investment Trust

					/s/ Peter P. D'Angelo, President of
					Cadence Trust Company, Trustee

Date: 07/27/2012			Kovner 2012-D Synta Investment Trust

					/s/ Peter P. D'Angelo, President of
					Cadence Trust Company, Trustee

Date: 07/27/2012			David Ben-Ur
                                        /s/ David Ben-Ur

					Bruce S. Kovner
Date: 07/27/2012
					/s/ Scott B. Bernstein,
                                        Attorney-in-Fact


The original statement shall be signed by each person on whose behalf the
statement is filed or his authorized representative. If the statement is
signed on behalf of a person by his authorized representative (other than
an executive officer or general partner of the filing person), evidence of
the representative's authority to sign on behalf of such person shall be
filed with the statement: provided, however, that a power of attorney for
this purpose which is already on file with the Commission may be incorporated
by reference.  The name and any title of each person who signs the statement
shall be typed or printed beneath his signature.

ATTENTION: Intentional misstatements or omissions of fact constitute Federal
criminal violations (See 18 U.S.C. 1001).


</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>